Aluminium lithium hydride → [5-(3-diethylamino-propyl)-1H-indol-2-yl]-methanol

HRID 1790903노트

반응식

HRID 1790903 반응식
C([O:3][C:4]([C:6]1[NH:7][C:8]2[C:13]([CH:14]=1)=[CH:12][C:11]([CH2:15][CH2:16][CH2:17][N:18]([CH2:21][CH3:22])[CH2:19][CH3:20])=[CH:10][CH:9]=2)=O)C.[H-].[Al+3].[Li+].[H-].[H-].[H-]>O1CCCC1>[CH2:21]([N:18]([CH2:19][CH3:20])[CH2:17][CH2:16][CH2:15][C:11]1[CH:12]=[C:13]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6]([CH2:4][OH:3])=[CH:14]2)[CH3:22]

참가 물질

4

반응물 2

HCID 21226445Aluminium lithium hydrideHCID 695872925-(3-Diethylamino-propyl)-1H-indole-2-carboxylic acid ethyl ester

생성물 1

HCID 22042151[5-(3-diethylamino-propyl)-1H-indol-2-yl]-methanol수율 66%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매2회

실험 절차

5-(3-Diethylamino-propyl)-1H-indole-2-carboxylic acid ethyl ester (1.2 g, 3.97 mmol) in tetrahydrofuran (48 mL) was added dropwise to the lithium aluminum hydride (602 mg, 15.87 mmol) stirred in tetrahydrofuran (30 mL) under nitrogen. After stirring for 2 hours, the reaction was quenched in water (0.6 mL), 15% sodium hydroxide (0.6 mL) and then water (1.8 mL). The mixture was stirred overnight. The precipitate was filtered off and the filtrate was concentrated to give 680 mg (66%) of [5-(3-diethylamino-propyl)-1H-indol-2-yl]-methanol.

후처리

  1. customthe reaction was quenched in water (0.6 mL)
  2. stirringThe mixture was stirred overnight
  3. filtrationThe precipitate was filtered off
  4. concentrationthe filtrate was concentrated

출처 및 근거

ORD 기록
ord-16b86cd36dd247ae86be41aa20a89b40
출처 데이터셋
uspto-grants-2006_07
특허 번호
US07071332B2

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