Benzaldehyde → 2-[2-Amino-4-(benzylamino)phenoxy]ethanol

HRID 1791085

반응식

HRID 1791085 반응식
[NH2:1][C:2]1[CH:11]=[C:10]([NH2:12])[CH:9]=[CH:8][C:3]=1[O:4][CH2:5][CH2:6][OH:7].[CH:13](=O)[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1.B.O1CCCC1>CO.O1CCCC1>[NH2:1][C:2]1[CH:11]=[C:10]([NH:12][CH2:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH:9]=[CH:8][C:3]=1[O:4][CH2:5][CH2:6][OH:7]

참가 물질

6

반응물 3

HCID 240BenzaldehydeHCID 479332-(2,4-Diaminophenoxy)ethanolHCID 2723981Borane;tetrahydrofuran

생성물 1

HCID 220265492-[2-Amino-4-(benzylamino)phenoxy]ethanol

시약·촉매·용매 2

HCID 887Methanol용매HCID 8028Tetrahydrofuran용매

실험 절차

2.66 g (10 mmol) of 2-(2,4-diaminophenoxy)ethanol and 1.06 g (10 mmol) of benzaldehyde were dissolved in methanol (dried over molecular sieve). After addition of 10 mg of molecular sieve, the reaction mixture was allowed to agitate 7 hours. Then, 20 mL of a solution of borane-tetrahydrofuran com-plex (1 M in tetrahydrofuran) was added at 0° C., and the reaction mixture was allowed to agitate one hour at room temperature. At the end of the reaction, the reaction mixture was filtered and hydrolyzed. The precipitate was filtered off, washed with water and then dried.

후처리

  1. additionAfter addition of 10 mg of molecular sieve
  2. stirringto agitate one hour at room temperature
  3. customAt the end of the reaction
  4. filtrationthe reaction mixture was filtered
  5. filtrationThe precipitate was filtered off
  6. washwashed with water
  7. customdried

출처 및 근거

ORD 기록
ord-07a7655d22c44b9194cd699db25c9830
출처 데이터셋
uspto-grants-2006_07
특허 번호
US07074243B2

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