1,4-Dibromo-2-nitrobenzene → 4-Bromo-2-nitrobenzonitrile
반응식
Br[C:2]1[CH:7]=[CH:6][C:5]([Br:8])=[CH:4][C:3]=1[N+:9]([O-:11])=[O:10].[C:12]([Cu])#[N:13]>CC(N(C)C)=O.CCOC(C)=O>[Br:8][C:5]1[CH:6]=[CH:7][C:2]([C:12]#[N:13])=[C:3]([N+:9]([O-:11])=[O:10])[CH:4]=1참가 물질
5
실험 절차
Stir the mixture of 1,4-dibromo-2-nitro-benzene (3.56 mmol)and CuCN (3.74 mmol) in DMA (4 ml) at 100° C. for 5hours. Cool to room temperature, dilute with EtOAc, filter through celite, wash the organic layer with brine, dry over Na2SO4, and concentrate under vacuum. Purify the residue by flash chromatography (4:1 hexanes/EtOAc) to give 4-bromo-2-nitro-benzonitrile.
후처리
- filtrationfilter through celite
- washwash the organic layer with brine
- dry with materialdry over Na2SO4
- concentrationconcentrate under vacuum
- customPurify the residue by flash chromatography (4:1 hexanes/EtOAc)
출처 및 근거
- ORD 기록
- ord-4080763d33fc4969b23659b3cd2ed48e
- 출처 데이터셋
- uspto-grants-2006_07
- 특허 번호
- US07074799B2
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