2-Amino-o-cresol → 3-t-Butoxycarbonylamino-2-methylphenol

HRID 1791852

반응식

HRID 1791852 반응식
[NH2:1][C:2]1[C:3]([CH3:9])=[C:4]([OH:8])[CH:5]=[CH:6][CH:7]=1.[C:10]([O:14][C:15](=O)[O:16]C(C)(C)C)([CH3:13])([CH3:12])[CH3:11]>C1COCC1>[C:10]([O:14][C:15]([NH:1][C:2]1[C:3]([CH3:9])=[C:4]([OH:8])[CH:5]=[CH:6][CH:7]=1)=[O:16])([CH3:13])([CH3:12])[CH3:11]

참가 물질

4

반응물 2

HCID 1044482-Amino-o-cresolHCID 10219638Carbonic acid, bis(1,1-dimethylethyl) ester

생성물 1

HCID 220334873-t-Butoxycarbonylamino-2-methylphenol수율 69%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

3-Amino-2-methylphenol (2.0 g; 16 mmol) and di-t-butylcarbonate were dissolved in THF (20 mL) and refluxed overnight. Evaporation of the solvent followed by flash chromatography (SiO2; EtOAc 5–30% in isohexane) afforded 2.48 g (69%) of the sub-title compound.

후처리

  1. temperaturerefluxed overnight
  2. customEvaporation of the solvent

출처 및 근거

ORD 기록
ord-7d57a165596141cbaf972e1129adb4f6
출처 데이터셋
uspto-grants-2006_07
특허 번호
US07074820B2

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