Diethanolamine → 4-[N,N-bis(2-hydroxyethyl)amino]-2-trifluoromethylquinoline

HRID 1791945

반응식

HRID 1791945 반응식
[NH:1]([CH2:5][CH2:6][OH:7])[CH2:2][CH2:3][OH:4].Cl[C:9]1[C:18]2[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=2)[N:12]=[C:11]([C:19]([F:22])([F:21])[F:20])[CH:10]=1>[Cl-].[Na+].O>[OH:4][CH2:3][CH2:2][N:1]([C:9]1[C:18]2[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=2)[N:12]=[C:11]([C:19]([F:22])([F:20])[F:21])[CH:10]=1)[CH2:5][CH2:6][OH:7]

참가 물질

4

반응물 2

HCID 8113DiethanolamineHCID 27367094-Chloro-2-(trifluoromethyl)quinoline

생성물 1

HCID 220288874-[N,N-bis(2-hydroxyethyl)amino]-2-trifluoromethylquinoline

시약·촉매·용매 1

HCID 57417360Sodium chloride; water용매

반응 조건

온도
80 °C

실험 절차

Diethanolamine (20 mL) was added to 4-chloro-2-trifluoromethylquinoline (5.04 g), and the mixture was stirred at 80° C. for 19 hr. Brine was added to the reaction mixture, and the mixture was extracted with ethyl acetate. The extract was dried and concentrated under reduced pressure. The residue was purified by silica gel chromatography to give 4-[N,N-bis(2-hydroxyethyl)amino]-2-trifluoromethylquinoline (3.40 g) as a white powder.

후처리

  1. extractionthe mixture was extracted with ethyl acetate
  2. customThe extract was dried
  3. concentrationconcentrated under reduced pressure
  4. customThe residue was purified by silica gel chromatography

출처 및 근거

ORD 기록
ord-4ef913eea72040918018fad2ac95998a
출처 데이터셋
uspto-grants-2006_07
특허 번호
US07074794B2

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