Allyl bromide → 7-Allyl-8-chloro-3-methyl-3,7-dihydropurine-2,6-dione

HRID 1791993노트

반응식

HRID 1791993 반응식
[Cl:1][C:2]1[NH:10][C:9]2[C:8](=[O:11])[NH:7][C:6](=[O:12])[N:5]([CH3:13])[C:4]=2[N:3]=1.C(=O)([O-])[O-].[K+].[K+].[CH2:20](Br)[CH:21]=[CH2:22]>CN(C)C=O.C(OCC)(=O)C.O>[CH2:22]([N:10]1[C:9]2[C:8](=[O:11])[NH:7][C:6](=[O:12])[N:5]([CH3:13])[C:4]=2[N:3]=[C:2]1[Cl:1])[CH:21]=[CH2:20]

참가 물질

7

반응물 3

HCID 7841Allyl bromideHCID 11430Potassium CarbonateHCID 126175848-chloro-3-methyl-2,3,6,9-tetrahydro-1H-purine-2,6-dione

생성물 1

HCID 220295197-Allyl-8-chloro-3-methyl-3,7-dihydropurine-2,6-dione

시약·촉매·용매 3

HCID 962Water용매HCID 6228Dimethylformamide용매HCID 8857Ethyl Acetate용매

실험 절차

8-Chloro-3-methyl-3,7-dihydropurine-2,6-dione (868 mg) and potassium carbonate (628 mg) were suspended in N,N-dimethylformamide (10 ml), and allyl bromide was added dropwise thereto while cooling on ice. After stirring the reaction mixture at room temperature for 17 hours, the resulting white suspension was diluted with ethyl acetate (30 ml) and water (4 ml), and was filtered to give a white solid. The solid was washed with water and ethyl acetate to give 797 mg of the title compound.

후처리

  1. temperaturewhile cooling on ice
  2. filtrationwas filtered
  3. customto give a white solid
  4. washThe solid was washed with water and ethyl acetate

출처 및 근거

ORD 기록
ord-eba40e1b03a04e9bac81fafb421d9fb6
출처 데이터셋
uspto-grants-2006_07
특허 번호
US07074798B2

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