Alfentanil Hydrochloride → Alfentanil
반응식
[CH3:1][CH2:2][C:3]([N:5]([C:12]1([CH2:28][O:29][CH3:30])[CH2:17][CH2:16][N:15]([CH2:18][CH2:19][N:20]2[N:25]=[N:24][N:23]([CH2:26][CH3:27])[C:21]2=[O:22])[CH2:14][CH2:13]1)[C:6]1[CH:7]=[CH:8][CH:9]=[CH:10][CH:11]=1)=[O:4].Cl>O>[CH3:1][CH2:2][C:3]([N:5]([C:12]1([CH2:28][O:29][CH3:30])[CH2:13][CH2:14][N:15]([CH2:18][CH2:19][N:20]2[N:25]=[N:24][N:23]([CH2:26][CH3:27])[C:21]2=[O:22])[CH2:16][CH2:17]1)[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)=[O:4]참가 물질
3
시약·촉매·용매 1
실험 절차
The alfentanil HCl obtained from step 7 is recrystallized from an HCl solution to give the final product as follows. 60.5 g of alfentanil HCl is placed into 2.5× amount of water (151 g H2O). To this is added 5.2 g activated charcoal and 10.4 g filtration aid (diatomaceous earth). Then 15.1 mL concentrated HCl is added (0.25 mL/g alfentanil HCl) and this is stirred until a slurry forms. This is followed by addition of 1 mL 1 N HCl/g alfentanil HCl (60.5 mL of 1 N HCl in this Example). This is chilled for over 2 hours and then filtered. The product is dried at approximately 40–55° C. until it is a constant weight. This final product is a monohydrate form of alfentanil HCl.
후처리
- customThe alfentanil HCl obtained from step 7 is recrystallized from an HCl solution