Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Bis(trifluoroacetoxy)iodobenzene → 3-(2,4-Difluoro-phenylsulfanyl)-6-methanesulfonyl-1H-indole-2-carboxylic acid methyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Bis(trifluoroacetoxy)iodobenzene | HCID 102317 | — |
| 반응물 | 2,4-Difluorobenzene-1-thiol | HCID 2737073 | — |
| 반응물 | methyl 6-(methylsulfonyl)-1H-indole-2-carboxylate | HCID 7141904 | — |
| 용매 | 1,1,1,3,3,3-Hexafluoro-2-propanol | HCID 13529 | — |
| 생성물 | 3-(2,4-Difluoro-phenylsulfanyl)-6-methanesulfonyl-1H-indole-2-carboxylic acid methyl ester | HCID 11418074 | 88% |
반응 단계
A solution of 2-carbomethoxy-6-methylsulfonylindole (750 mg, 2.8 mmol), in 10 mL hexafluoroisopropanol was treated with 2,4-difluorothiophenol (7.5 mmol) followed by addition of PIFA (5.6 mmol). The dark colored solution was stirred overnight then partitioned between methylene chloride and water. After concentration of the methylene chloride layer to 20 mL the product was precipitated by addition of 30 mL hexane. An 88% yield of 3-(2,4-difluoro-phenylsulfanyl)-6-methanesulfonyl-1H-indole-2-carboxylic acid methyl ester was obtained.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07074939B2 |
| 출처 데이터셋 | uspto-grants-2006_07 |
| ORD ID | ord-523b1051d6cf45ca941f7f0badcea3ce |
| 출처 메모 | uspto-grants-2006_07 |