2-(5-Bromo-2-pyridinylamino)-1-cyanoethyl toluene-4-sulfonate → 6-Bromo-2,3-dihydroimidazo[1,2-a]pyridine-3-carbonitrile

HRID 1792458노트

반응식

HRID 1792458 반응식
C1(C)C=CC(S(O[CH:11]([C:21]#[N:22])[CH2:12][NH:13][C:14]2[CH:19]=[CH:18][C:17]([Br:20])=[CH:16][N:15]=2)(=O)=O)=CC=1>C(#N)C>[Br:20][C:17]1[CH:18]=[CH:19][C:14]2[N:15]([CH:11]([C:21]#[N:22])[CH2:12][N:13]=2)[CH:16]=1

참가 물질

3

반응물 1

HCID 235374122-(5-Bromo-2-pyridinylamino)-1-cyanoethyl toluene-4-sulfonate

생성물 1

HCID 220317966-Bromo-2,3-dihydroimidazo[1,2-a]pyridine-3-carbonitrile수율 88.7%

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

7.64 g of 2-(5-bromo-2-pyridinylamino)-1-cyanoethyl toluene-4-sulfonate was dissolved in 76 mL acetonitrile, and the mixture was heated for 15 hours under reflux. After the solvent was removed, an aqueous saturated sodium bicarbonate was poured into the reaction product which was then extracted with dichloromethane, and the organic layer was dried over anhydrous sodium sulfate and filtered through NH silica gel. The solvent was removed, whereby 3.83 g of the title compound (yellow solid) was obtained.

후처리

  1. temperaturethe mixture was heated for 15 hours
  2. temperatureunder reflux
  3. customAfter the solvent was removed
  4. additionan aqueous saturated sodium bicarbonate was poured into the reaction product which
  5. extractionwas then extracted with dichloromethane
  6. dry with materialthe organic layer was dried over anhydrous sodium sulfate
  7. filtrationfiltered through NH silica gel
  8. customThe solvent was removed

출처 및 근거

ORD 기록
ord-fa9d214665694c878069c3dfffe8226b
출처 데이터셋
uspto-grants-2006_07
특허 번호
US07074801B1

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