Trifluoroacetic acid → HCID 178434508, 화합물

반응식

[CH3:1][N:2]([CH3:46])[C:3]([N:5]1[CH2:10][CH2:9][N:8]([C:11]2[C:20]3[C:15](=[CH:16][CH:17]=[C:18]([C:21]4[C:22]([CH3:45])=[N:23][N:24](C(C5C=CC=CC=5)(C5C=CC=CC=5)C5C=CC=CC=5)[CH:25]=4)[CH:19]=3)[N:14]=[CH:13][CH:12]=2)[CH2:7][CH2:6]1)=[O:4].FC(F)(F)C(O)=O>>[CH3:1][N:2]([CH3:46])[C:3]([N:5]1[CH2:6][CH2:7][N:8]([C:11]2[C:20]3[C:15](=[CH:16][CH:17]=[C:18]([C:21]4[C:22]([CH3:45])=[N:23][NH:24][CH:25]=4)[CH:19]=3)[N:14]=[CH:13][CH:12]=2)[CH2:9][CH2:10]1)=[O:4]

참가 물질

반응물 2

HCID 6422Trifluoroacetic acid

HCID 23537795HCID 23537795, 화합물

생성물 1

HCID 178434508HCID 178434508, 화합물수율 70.1%

실험 절차

38 mg N,N-dimethyl 4-[6-(3-methyl-1-trityl-1H-pyrazolyl)-4-quinolyl]-1-piperazine carboxamide obtained in Example 182 and 0.2 mL trifluoroacetic acid were reacted in the same manner as in Example 165, to give 16 mg of the title compound as pale yellow crystals.

출처 및 근거

ORD 기록: ord-5f2bbce63b7b434e86998dcb5ac0ff9f
출처 데이터셋: uspto-grants-2006_07
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07074801B1

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