Trifluoroacetic acid → N,N-Dimethyl-4-[6-(3-methyl-1H-4-pyrazolyl)-4-quinolyl]-1-piperazine sulfonamide
반응식
[CH3:1][N:2]([CH3:47])[S:3]([N:6]1[CH2:11][CH2:10][N:9]([C:12]2[C:21]3[C:16](=[CH:17][CH:18]=[C:19]([C:22]4[C:23]([CH3:46])=[N:24][N:25](C(C5C=CC=CC=5)(C5C=CC=CC=5)C5C=CC=CC=5)[CH:26]=4)[CH:20]=3)[N:15]=[CH:14][CH:13]=2)[CH2:8][CH2:7]1)(=[O:5])=[O:4].FC(F)(F)C(O)=O>>[CH3:1][N:2]([CH3:47])[S:3]([N:6]1[CH2:11][CH2:10][N:9]([C:12]2[C:21]3[C:16](=[CH:17][CH:18]=[C:19]([C:22]4[C:23]([CH3:46])=[N:24][NH:25][CH:26]=4)[CH:20]=3)[N:15]=[CH:14][CH:13]=2)[CH2:8][CH2:7]1)(=[O:4])=[O:5]참가 물질
3
실험 절차
37 mg N,N-dimethyl-4-[6-(3-methyl-1-trityl-1H-pyrazolyl)-4-quinolyl]-1-piperazine sulfonamide obtained in Example 183 and 0.2 mL trifluoroacetic acid were reacted in the same manner as in Example 165, to give 16 mg of the title compound as pale yellow crystals.
출처 및 근거
- ORD 기록
- ord-10d1169e32a1472798369eb75577d4b3
- 출처 데이터셋
- uspto-grants-2006_07
- 특허 번호
- US07074801B1
반응 노트
불러오는 중…