HCID 23537502, 화합물 → HCID 178488643, 화합물

HRID 1792631노트

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HRID 1792631 반응식
[CH3:1][O:2][C:3]1[N:8]=[CH:7][C:6]([C:9]2[C:18]3[C:13](=[CH:14][CH:15]=[C:16]([C:19]4[C:20]([C:43]([F:46])([F:45])[F:44])=[N:21][N:22](C(C5C=CC=CC=5)(C5C=CC=CC=5)C5C=CC=CC=5)[CH:23]=4)[CH:17]=3)[N:12]=[CH:11][CH:10]=2)=[CH:5][CH:4]=1>FC(F)(F)C(O)=O>[CH3:1][O:2][C:3]1[N:8]=[CH:7][C:6]([C:9]2[C:18]3[C:13](=[CH:14][CH:15]=[C:16]([C:19]4[C:20]([C:43]([F:45])([F:44])[F:46])=[N:21][NH:22][CH:23]=4)[CH:17]=3)[N:12]=[CH:11][CH:10]=2)=[CH:5][CH:4]=1

참가 물질

3

반응물 1

HCID 23537502HCID 23537502, 화합물

생성물 1

HCID 178488643HCID 178488643, 화합물수율 86.7%

시약·촉매·용매 1

HCID 6422Trifluoroacetic acid용매

실험 절차

A mixture of 210 mg 4-(6-methoxypyridin-3-yl)-6-(3-trifluoromethyl-1-trityl-1H-pyrazol-4-yl) quinoline obtained in Example 1063 and 10 mL trifluoroacetic acid was stirred at room temperature for 1 hour. The trifluoroacetic acid was evaporated, and an aqueous saturated sodiumbicarbonate solution was added to the residue which was then extracted with ethyl acetate. The organic layer was washed with brine and dried over anhydrous magnesium sulfate. The solvent was evaporated, and the residue was purified by silica gel column chromatography to give 110 mg of the title compound as a colorless solid.

후처리

  1. customThe trifluoroacetic acid was evaporated
  2. additionan aqueous saturated sodiumbicarbonate solution was added to the residue which
  3. extractionwas then extracted with ethyl acetate
  4. washThe organic layer was washed with brine
  5. dry with materialdried over anhydrous magnesium sulfate
  6. customThe solvent was evaporated
  7. customthe residue was purified by silica gel column chromatography

출처 및 근거

ORD 기록
ord-5598c05e55684dffb547e8df1b32f1b8
출처 데이터셋
uspto-grants-2006_07
특허 번호
US07074801B1

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