3-Amino-4-methoxybenzoic acid → 3-[3-(2,4-Dichlorobenzoyl)ureido]-4-methoxybenzoic acid

HRID 1792744

반응식

HRID 1792744 반응식
[NH2:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[O:11][CH3:12])[C:5]([OH:7])=[O:6].[Cl:13][C:14]1[CH:24]=[C:23]([Cl:25])[CH:22]=[CH:21][C:15]=1[C:16]([N:18]=[C:19]=[O:20])=[O:17]>C(#N)C>[Cl:13][C:14]1[CH:24]=[C:23]([Cl:25])[CH:22]=[CH:21][C:15]=1[C:16]([NH:18][C:19](=[O:20])[NH:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[O:11][CH3:12])[C:5]([OH:7])=[O:6])=[O:17]

참가 물질

4

반응물 2

HCID 178233-Amino-4-methoxybenzoic acidHCID 116298872,4-Dichlorobenzoyl isocyanate

생성물 1

HCID 98862873-[3-(2,4-Dichlorobenzoyl)ureido]-4-methoxybenzoic acid수율 96%

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

20 g (120 mmol) of 3-amino-4-methoxybenzoic acid were made to react with 36 g (168 mmol) of 2,4-dichlorobenzoyl isocyanate from step a in 400 ml of acetonitrile and left to react therewith at reflux for 2 hours. After the mixture has cooled down to room temperature, the precipitate is filtered off with suction, washed twice with in each case 20 ml of acetonitrile, sucked dry and dried under high vacuum. 44 g (96%) of the desired product are obtained.

후처리

  1. waitleft
  2. customto react
  3. temperatureat reflux for 2 hours
  4. filtrationthe precipitate is filtered off with suction
  5. washwashed twice with in each case 20 ml of acetonitrile
  6. customsucked dry
  7. customdried under high vacuum

출처 및 근거

ORD 기록
ord-a4215c2a13f74ffca2c62378fa5f5a43
출처 데이터셋
uspto-grants-2006_07
특허 번호
US07078404B2

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