HCID 22024596, 화합물 → HCID 22024494, 화합물

HRID 1793067노트

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HRID 1793067 반응식
[Cl:1][C:2]1[C:3]2[N:4]([C:8]([CH:13]([OH:17])[CH2:14][CH2:15][CH3:16])=[C:9]([CH2:11][CH3:12])[N:10]=2)[CH:5]=[CH:6][N:7]=1>C(OCC)(=O)C.C(Cl)Cl.[O-2].[Mn+4].[O-2]>[Cl:1][C:2]1[C:3]2[N:4]([C:8]([C:13](=[O:17])[CH2:14][CH2:15][CH3:16])=[C:9]([CH2:11][CH3:12])[N:10]=2)[CH:5]=[CH:6][N:7]=1

참가 물질

5

반응물 1

HCID 22024596HCID 22024596, 화합물

생성물 1

HCID 22024494HCID 22024494, 화합물

시약·촉매·용매 3

HCID 178418406HCID 178418406, 화합물촉매HCID 6344Dichloromethane용매HCID 8857Ethyl Acetate용매

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온도
60 °C

실험 절차

The resulting 1-(8-chloro-2-ethylimidazo[1,2-a]pyrazin-3-yl)-1-butanol was dissolved in ethyl acetate (4 mL) and methylene chloride (1 mL), then activated manganese (IV) oxide (3 g) was added thereto, and the mixture was heated under stirring at 60° C. for 5 hours. After being allowed to cool, the reaction mixture was filtered and washed with ethyl acetate, and then the filtrates were combined and evaporated. The resulting residue was purified by silica gel column chromatography (ethyl acetate:n-hexane=1:3) to give the title compound (226 mg) as white crystals.

후처리

  1. temperaturethe mixture was heated
  2. temperatureto cool
  3. filtrationthe reaction mixture was filtered
  4. washwashed with ethyl acetate
  5. customevaporated
  6. customThe resulting residue was purified by silica gel column chromatography (ethyl acetate:n-hexane=1:3)

출처 및 근거

ORD 기록
ord-72159f0f66b74005a17e9d77b719b034
출처 데이터셋
uspto-grants-2006_07
특허 번호
US07078405B2

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