HCID 22024658, 화합물 → HCID 22024358, 화합물

HRID 1793085노트

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HRID 1793085 반응식
[Br:1][C:2]1[C:3]2[N:4]([CH2:8][CH:9]([CH2:11][CH3:12])[N:10]=2)[CH:5]=[N:6][CH:7]=1>C1(C)C=CC=CC=1.[O-2].[O-2].[Mn+4]>[Br:1][C:2]1[C:3]2[N:4]([CH:8]=[C:9]([CH2:11][CH3:12])[N:10]=2)[CH:5]=[N:6][CH:7]=1

참가 물질

4

반응물 1

HCID 22024658HCID 22024658, 화합물

생성물 1

HCID 22024358HCID 22024358, 화합물수율 43.7%

시약·촉매·용매 2

HCID 178418406HCID 178418406, 화합물촉매HCID 1140Toluene용매

반응 조건

온도
90 °C

실험 절차

8-Bromo-2-ethyl-2,3-dihydroimidazo[1,2-c]pyrimidine (3.0 g) was dissolved in toluene (60 mL), then activated manganese(IV) dioxide (3.5 g) was added thereto, and the mixture was heated under stirring at 90° C. for 1 day. Manganese(IV) oxide was filtered off through Celite, and the solvent was evaporated. The resulting residue was purified by silica gel column chromatography (ethyl acetate:n-hexane=1:10) to give the title compound (1.3 g) as white crystals.

후처리

  1. temperaturethe mixture was heated
  2. filtrationManganese(IV) oxide was filtered off through Celite
  3. customthe solvent was evaporated
  4. customThe resulting residue was purified by silica gel column chromatography (ethyl acetate:n-hexane=1:10)

출처 및 근거

ORD 기록
ord-f6be0fdcc7454cd9853af08eab5f7538
출처 데이터셋
uspto-grants-2006_07
특허 번호
US07078405B2

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