Cyclopentylamine → 1-cyclopentyl-4-nitro-1H-imidazole

반응식

[CH:1]1([NH2:6])[CH2:5][CH2:4][CH2:3][CH2:2]1.[N+](N1[CH:14]=[C:13]([N+:15]([O-:17])=[O:16])[N:12]=[CH:11]1)([O-])=O>>[CH:1]1([N:6]2[CH:14]=[C:13]([N+:15]([O-:17])=[O:16])[N:12]=[CH:11]2)[CH2:5][CH2:4][CH2:3][CH2:2]1

참가 물질

반응물 2

HCID 2906Cyclopentylamine

HCID 51694961,4-Dinitro-1H-imidazole

생성물 1

HCID 220259891-cyclopentyl-4-nitro-1H-imidazole수율 75%

실험 절차

This reaction was carried out using the procedure for Preparation 1 with cyclopentyl amine and 1,4-dinitroimidazole to afford 205 mg (75% yield) of 1-cyclopentyl-4-nitro-1H-imidazole; 1H NMR (400 MHz, CDCl3) δ 7.77 (s, 1H), 7.45 (s, 1H), 4.49 (m, 1H), 2.25 (m, 2H), 2.0–1.7 (m, 6H); MS (AP/CI): 182.2 (M+H)+.

출처 및 근거

ORD 기록: ord-394e4d26bd894add8e909419ab362dae
출처 데이터셋: uspto-grants-2006_07
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07078529B2

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