Ethyl Acrylate → N-[3-[bis(phenylmethyl)amino]propyl]-beta-alanine, ethyl ester

HRID 1793333노트

반응식

HRID 1793333 반응식
[NH2:1][CH2:2][CH2:3][CH2:4][N:5]([CH2:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)[CH2:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1.[C:20]([O:24][CH2:25][CH3:26])(=[O:23])[CH:21]=[CH2:22]>C(O)C>[C:7]1([CH2:6][N:5]([CH2:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH2:4][CH2:3][CH2:2][NH:1][CH2:22][CH2:21][C:20]([O:24][CH2:25][CH3:26])=[O:23])[CH:8]=[CH:9][CH:10]=[CH:11][CH:12]=1

참가 물질

4

반응물 2

HCID 8821Ethyl AcrylateHCID 11436748(3-Aminopropyl)dibenzylamine

생성물 1

HCID 131725872N-[3-[bis(phenylmethyl)amino]propyl]-beta-alanine, ethyl ester수율 39.1%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

Reaction under an argon flow. A mixture of 1-amino-3-dibenzylaminopropane (0.195 mol) in ethanol (225 ml) was stirred at room temperature. Ethyl propenoate (0.2 mol) was poured into the mixture and the reaction mixture was stirred overnight at room temperature. The solvent was evaporated. The residue was purified by column chromatography over silica gel (eluent: CH2Cl2/hexane/CH3OH 50/45/5). The desired fractions were collected and the solvent was evaporated, yielding 27 g of N-[3-[bis(phenylmethyl)amino]propyl]-β-alanine, ethyl ester (intermediate 52).

후처리

  1. customReaction under an argon flow
  2. stirringthe reaction mixture was stirred overnight at room temperature
  3. customThe solvent was evaporated
  4. customThe residue was purified by column chromatography over silica gel (eluent: CH2Cl2/hexane/CH3OH 50/45/5)
  5. customThe desired fractions were collected
  6. customthe solvent was evaporated

출처 및 근거

ORD 기록
ord-b5cf7d59486349e89fab2b0620de818e
출처 데이터셋
uspto-grants-2006_07
특허 번호
US07081453B2

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