Ethyl Bromide → 3-(Naphthalen-2-yloxy)propan-1-amine

HRID 1793494

반응식

HRID 1793494 반응식
COC1C=CC([NH:9][CH2:10][CH2:11][CH2:12][O:13][C:14]2[CH:23]=[CH:22][C:21]3[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=3)[CH:15]=2)=CC=1.C(Br)C>CC(C)=O>[CH:15]1[C:16]2[C:21](=[CH:20][CH:19]=[CH:18][CH:17]=2)[CH:22]=[CH:23][C:14]=1[O:13][CH2:12][CH2:11][CH2:10][NH2:9]

참가 물질

4

반응물 2

HCID 6332Ethyl BromideHCID 9839556(4-Methoxyphenyl)-(3-(naphthalen-2-yloxy)propyl)amine

생성물 1

HCID 167907513-(Naphthalen-2-yloxy)propan-1-amine

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

A mixture of N-(4-methoxyphenyl)-[3-(naphthalen-2-yloxy)propyl]amine (0.5 gm, 0.002 mole) and ethyl bromide(0.52 ml, 0.003 mole) was taken in dry acetone (40 ml). It was refluxed for 12 hrs and the progress of reaction checked by TLC. Reaction mixture was filtered and the filtrate was concentrated to get oily compound which was further crystallized by benzene hexane mixture to get N-(4 methoxyphenyl)-N-ethyl [3-(naphthalen-2-yloxy)propylamine, crystallized as yellow oil, (yield 0.64 gm, 94.6%).

후처리

  1. temperatureIt was refluxed for 12 hrs
  2. customthe progress of reaction
  3. customReaction mixture
  4. filtrationwas filtered
  5. concentrationthe filtrate was concentrated
  6. customto get oily compound which
  7. customwas further crystallized by benzene hexane mixture

출처 및 근거

ORD 기록
ord-c7a8b54195494acfa10a4169a5ff2089
출처 데이터셋
uspto-grants-2006_07
특허 번호
US07081465B2

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