Trimethyl phosphite → (4-Chlorobenzyl)-phosphonic acid dimethyl ester

HRID 1793645노트

반응식

HRID 1793645 반응식
[CH3:1][O:2][P:3]([O:6]C)[O:4][CH3:5].[Cl:8][C:9]1[CH:16]=[CH:15][C:12]([CH2:13]Br)=[CH:11][CH:10]=1>>[CH3:1][O:2][P:3]([CH2:13][C:12]1[CH:15]=[CH:16][C:9]([Cl:8])=[CH:10][CH:11]=1)(=[O:6])[O:4][CH3:5]

참가 물질

3

반응물 2

HCID 8472Trimethyl phosphiteHCID 693291-(Bromomethyl)-4-chlorobenzene

생성물 1

HCID 12266546(4-Chlorobenzyl)-phosphonic acid dimethyl ester수율 93%

실험 절차

To a stirred solution of trimethylphosphite (0.57 ml, 4.9 mmol) was added 4-chlorobenzylbromide (1.0 g, 4.9 mmol) at rt. The resulting mixture was stirred at rt for 5 min. and then heated in an oil bath at 80° C. for 20 min. It was cooled to rt and the product purified on a silica-gel column with 25% EtOAc in hexane to give 1.05 g of (4-chloro-benzyl)-phosphonic acid dimethyl ester (93%).

후처리

  1. temperatureheated in an oil bath at 80° C. for 20 min
  2. temperatureIt was cooled to rt
  3. customthe product purified on a silica-gel column with 25% EtOAc in hexane

출처 및 근거

ORD 기록
ord-eb248a4f42a842708b15e43336f8ae83
출처 데이터셋
uspto-grants-2006_07
특허 번호
US07081531B2

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