Bromoacetic Acid → HCID 22220817, 화합물

HRID 1794041노트

반응식

HRID 1794041 반응식
[S:1]1[CH:5]=[CH:4][N:3]=[C:2]1[CH:6]([OH:8])[CH3:7].Br[CH2:10][C:11]([OH:13])=[O:12]>O>[C:11]([CH2:10][N:3]1[CH:4]=[CH:5][S:1][CH:2]1[CH:6]([OH:8])[CH3:7])([OH:13])=[O:12]

참가 물질

4

반응물 2

HCID 6227Bromoacetic Acid2회HCID 99892951-(1,3-Thiazol-2-yl)ethan-1-ol

생성물 1

HCID 22220817HCID 22220817, 화합물수율 107.9%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

1-(2-Thiazolyl)ethanol (0.5 g, 3.87 mmole) and bromoacetic acid (0.538 g, 3.87 mmole) were warmed to melt the bromoacetic acid, then were allowed to cool and were stirred 4 days at room temp. The mixture was dissolved in 15–20 mL water and extracted with 4×10 mL ether. The water layer was evaporated in vacuo to give 0.79 g of residue, which was stored under 30 mL acetonitrile at room temp. overnight to effect crystalization. Filtration and washing with 30% ether/acetonitrile gave 0.335 g of the title compound, mp 160–161 C.

후처리

  1. temperatureto cool
  2. extractionextracted with 4×10 mL ether
  3. customThe water layer was evaporated in vacuo

출처 및 근거

ORD 기록
ord-b2dfab04c77c4ca6bc79b9876a99a97d
출처 데이터셋
uspto-grants-2006_04
특허 번호
US07022721B1

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