Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1-Iodopropane → (R)-2,6-Difluoro-4-propoxybenzyl 2-methylpiperazine-1-carboxylate fumarate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1-Iodopropane | HCID 33643 | — |
| 반응물 | (R)-4-Difluoromethoxybenzyl 2-ethylpiperazine-1-carboxylate fumarate | HCID 21021913 | — |
| 반응물 | 3,5-Difluoro-4-(hydroxymethyl)phenol | HCID 22219975 | — |
| 생성물 | (R)-2,6-Difluoro-4-propoxybenzyl 2-methylpiperazine-1-carboxylate fumarate | HCID 21021908 | — |
반응 단계
(R)-2,6-Difluoro-4-propoxybenzyl 2-methylpiperazine-1-carboxylate fumarate was prepared from (R) 1-chlorocarbonyl-2-methyl-4-tert-butoxycarbonylpiperazine, 1-iodopropane and 2,6-difluoro-4-hydroxybenzyl alcohol according to the methods described for Examples 54 and 96 to give the product as a white solid (19.2%); melting point 193.9–194.0° C.; NMR δH (400 MHz, DMSO-d6) 0.958(3H, t, J 7.5 Hz), 1.140(3H, d, J 7.0 Hz), 1.715(2H, m), 2.817(2H, m), 2.982(2H, m), 3.687(2H, m), 4.097(1H, bs), 5.027(2H, q, J 11.0 Hz), 6.573(2H, s) and 6.773(2H, d, J 10.0 Hz).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07022707B2 |
| 출처 데이터셋 | uspto-grants-2006_04 |
| ORD ID | ord-8de8cbb695424bc78d4ab623c845748a |
| 출처 메모 | uspto-grants-2006_04 |