4-(Difluoromethoxy)benzyl alcohol → (R)-4-Difluoromethoxybenzyl 2-methylpiperazine-1-carboxylate fumarate

HRID 1794104

반응식

HRID 1794104 반응식
[C:1]([OH:8])(=[O:7])/[CH:2]=[CH:3]/[C:4]([OH:6])=[O:5].[CH2:9]([C@@H:11]1[CH2:16][NH:15][CH2:14][CH2:13][N:12]1[C:17]([O:19][CH2:20][C:21]1[CH:26]=[CH:25][C:24]([O:27][CH:28]([F:30])[F:29])=[CH:23][CH:22]=1)=[O:18])C.FC(F)OC1C=CC(CO)=CC=1>>[C:1]([OH:8])(=[O:7])/[CH:2]=[CH:3]/[C:4]([OH:6])=[O:5].[CH3:9][C@@H:11]1[CH2:16][NH:15][CH2:14][CH2:13][N:12]1[C:17]([O:19][CH2:20][C:21]1[CH:26]=[CH:25][C:24]([O:27][CH:28]([F:30])[F:29])=[CH:23][CH:22]=1)=[O:18]

참가 물질

3

반응물 2

HCID 27369964-(Difluoromethoxy)benzyl alcoholHCID 21021913(R)-4-Difluoromethoxybenzyl 2-ethylpiperazine-1-carboxylate fumarate

생성물 1

HCID 21021915(R)-4-Difluoromethoxybenzyl 2-methylpiperazine-1-carboxylate fumarate

실험 절차

(R)-4-Difluoromethoxybenzyl 2-methylpiperazine-1-carboxylate fumarate was prepared from (R) 1-chlorocarbonyl-2-methyl-4-tert-butoxycarbonylpiperazine and 4-difluoromethoxybenzyl alcohol according to the methods described for Examples 48 and 54 to give the product as a white solid (24.0%); melting point 123.9–124.5° C.; NMR δH (400 MHz, DMSO-d6) 1.174(3H, d, J 7.0 Hz), 2.622(1H, m), 3.003(2H, m), 3.766(1H, dd, J 2.5, 13 Hz), 4.187(1H, m), 5.067(2H, m), 6.542 (2H, s), 7.178(2H, d, J 9.0 Hz), 7.244(1H, t, J 74.0) and 7.424(2H, d, J 8.5 Hz).

출처 및 근거

ORD 기록
ord-70ab0de6747d4c6b975620c7fec6c360
출처 데이터셋
uspto-grants-2006_04
특허 번호
US07022707B2

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