3,4-Difluorobenzyl Chloride → 2,6-Difluoro-4-(3,4-difluorobenzyl)oxybenzyl cis-2,6-dimethylpiperazine-1-carboxylate

참여 물질

역할	이름	HCID	투입량
반응물	3,4-Difluorobenzyl Chloride	HCID 2736954	—
반응물	rac-tert-butyl (3R,5S)-4-(carboxy)-3,5-dimethylpiperazine-1-carboxylate	HCID 22219933	—
반응물	3,5-Difluoro-4-(hydroxymethyl)phenol	HCID 22219975	—
생성물	2,6-Difluoro-4-(3,4-difluorobenzyl)oxybenzyl cis-2,6-dimethylpiperazine-1-carboxylate	HCID 69141543	—

반응 단계

2,6-Difluoro-4-(3,4-difluorobenzyl)oxybenzyl cis-2,6-dimethylpiperazine-1-carboxylate was prepared from 2,6-difluoro-4-hydroxybenzyl alcohol, 3,4-difluorobenzyl chloride and 1-chlorocarbonyl-2,6-dimethyl-4-tert-butoxycarbonylpiperazine according to the methods described for Example 54 and 121 to give the product as a yellow oil: δH (400 MHz; d6-DMSO) 1.13 (6H, d, J 7.0 Hz), 2.60 (2H, dd, J 12.0, 4.5 Hz), 2.66 (2H, d, J 12.0 Hz), 3.77–3.85 (2H, m), 5.04 (2H, s), 5.13 (2H, s), 6.84–6.92 (2H, m), 7.29–7.35 (1H, m), 7.48 (1H, dt, J 11.0, 8.5 Hz) and 7.55 (1H, ddd, J 11.5, 7.5, 2.5 Hz); HPLC (XTERRA, 50–80%, 220 nm) 99.5% (6.17 min).

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US07022707B2
출처 데이터셋	uspto-grants-2006_04
ORD ID	ord-ade11351209441918d7255fa332d3939
출처 메모	uspto-grants-2006_04