4-(Chloromethyl)-2-methyl-1,3-thiazole → 2,6-Difluoro-4-[(2-methyl-4-thiazolyl)methoxy]benzenemethanol
반응식
[F:1][C:2]1[CH:3]=[C:4]([OH:11])[CH:5]=[C:6]([F:10])[C:7]=1[CH2:8][OH:9].Cl[CH2:13][C:14]1[N:15]=[C:16]([CH3:19])[S:17][CH:18]=1>>[F:1][C:2]1[CH:3]=[C:4]([O:11][CH2:13][C:14]2[N:15]=[C:16]([CH3:19])[S:17][CH:18]=2)[CH:5]=[C:6]([F:10])[C:7]=1[CH2:8][OH:9]참가 물질
3
실험 절차
This compound was prepared from 3,5-difluoro-4-hydroxymethyl-phenol and 4-chlormethyl-2-methylthiazol according to the procedure described in Example 179 to give the product as a colorless oil (369 mg, 73%); MS (ISP): 272.3 (M+H)+.
출처 및 근거
- ORD 기록
- ord-d1e7f5499b5c414ebae3b44093005352
- 출처 데이터셋
- uspto-grants-2006_04
- 특허 번호
- US07022707B2
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