Hydrogen chloride-ethyl acetate → HCID 69663689, 화합물

HRID 1794226노트

반응식

HRID 1794226 반응식
[CH2:1]([O:3][C:4]([C@@H:6]1[O:11][C:10]2[CH:12]=[CH:13][C:14]([CH2:16][C@H:17]([NH:19][CH2:20][C@H:21]([OH:41])[CH2:22][O:23][C:24]3[CH:29]=[C:28]([O:30][CH3:31])[C:27]([O:32]COC)=[C:26]([NH:36][S:37]([CH3:40])(=[O:39])=[O:38])[CH:25]=3)[CH3:18])=[CH:15][C:9]=2[O:8][CH2:7]1)=[O:5])[CH3:2].[ClH:42].CCOC(C)=O>C(O)C>[ClH:42].[CH2:1]([O:3][C:4]([C@@H:6]1[O:11][C:10]2[CH:12]=[CH:13][C:14]([CH2:16][C@H:17]([NH:19][CH2:20][C@H:21]([OH:41])[CH2:22][O:23][C:24]3[CH:29]=[C:28]([O:30][CH3:31])[C:27]([OH:32])=[C:26]([NH:36][S:37]([CH3:40])(=[O:38])=[O:39])[CH:25]=3)[CH3:18])=[CH:15][C:9]=2[O:8][CH2:7]1)=[O:5])[CH3:2]

참가 물질

4

반응물 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 58618751HCID 58618751, 화합물

생성물 1

HCID 69663689HCID 69663689, 화합물수율 101.3%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

To a solution of 6-[2-(R)-[2-(S)-hydroxy-3-[3-methanesulfonamido-5-methoxy-4-(methoxymethoxy)phenoxy]-propylamino]propyl]-2,3-dihydro-1,4-benzodioxine-2-(R)-carboxylic acid ethyl ester (100 mg) obtained in Example 26 in ethanol (10 mL) was added 4N—HCl/AcOEt (1.0 mL, 4.0 mmol) at room temperature. This solution was stirred at room temperature for 16 hours and then concentrated to dryness under reduced pressure, affording the title compound (100 mg). Yield: 85%

후처리

  1. concentrationconcentrated to dryness under reduced pressure

출처 및 근거

ORD 기록
ord-7daf66e0efb344eabcd7e33ab30120ca
출처 데이터셋
uspto-grants-2006_04
특허 번호
US07022732B2

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