N-Acetylsulfanilyl chloride → N-{4-[2-(1,4-Dioxa-8-aza-spiro[4.5]dec-8-yl)-phenylsulfamoyl]-phenyl]-acetamide
반응식
Cl.[O:2]1[C:6]2([CH2:11][CH2:10][N:9]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=3[NH2:18])[CH2:8][CH2:7]2)[O:5][CH2:4][CH2:3]1.[C:19]([NH:22][C:23]1[CH:32]=[CH:31][C:26]([S:27](Cl)(=[O:29])=[O:28])=[CH:25][CH:24]=1)(=[O:21])[CH3:20]>>[O:5]1[C:6]2([CH2:11][CH2:10][N:9]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=3[NH:18][S:27]([C:26]3[CH:25]=[CH:24][C:23]([NH:22][C:19](=[O:21])[CH3:20])=[CH:32][CH:31]=3)(=[O:29])=[O:28])[CH2:8][CH2:7]2)[O:2][CH2:3][CH2:4]1참가 물질
3
실험 절차
The title compound was prepared from 2-(1,4-dioxa-8-aza-spiro[4.5]dec-8-yl)-phenylamine hydrochloride (which was obtained in Example 220) and N-acetylsulfanilyl chloride according to the procedure of Example 215 as a crystalline solid; 1H NMR (300 MHz, DMSO-d6) δ 1.73 (t, J=5.4 Hz, 4 H), 2.73 (t, J=5.4 Hz, 4 H), 3.33 (s, 4 H), 3.89 (s, 3 H), 7.00–7.10 (m, 2 H), 7.10–7.20 (m, 1 H), 7.30–7.40 (m, 1 H), 7.67 (d, J=9.3 Hz, 2 H), 7.71 (d, J=9.3 Hz, 2 H), 8.79 (s, 1 H), 10.29 (s, 1 H); MS (ES) m/z: 432.2 (MH+); HRMS Calcd. for C21H26N3O5S (MH+): 432.1593. Found: 432.1597. Anal. Calcd. for C21N25N3O5S: C, 58.45; H, 5.84; N, 9.74. Found: C, 58.41; H, 5.83; N, 9.72.
출처 및 근거
- ORD 기록
- ord-034e14bf4204484f94658af10c8fce2e
- 출처 데이터셋
- uspto-grants-2006_04
- 특허 번호
- US07022716B2
반응 노트
불러오는 중…