Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → HCID 178418454, 화합물
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Sodium Azide | HCID 33557 | — |
| 반응물 | trans-7-Chloro-5-(2-chlorophenyl)-3-(3-cyanophenylaminocarbonylmethyl)-1-neopentyl-2-oxo-1,2,3,5-tetrahydro-4,1-benzoxazepine | HCID 69946147 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | HCID 178418454 | HCID 178418454 | 50.9% |
반응 단계
A solution of 0.2 g of trans-7-chloro-5-(2-chlorophenyl)-3-(3-cyanophenylaminocarbonylmethyl)-1-neopentyl-2-oxo-1,2,3,5-tetrahydro-4,1-benzoxazepine and 80 mg of sodium azide in 5 ml of dimethylformamide was stirred at 90° C. for 60 hours. After water was added, the mixture was washed with water, after which the solvent was removed and the residue was subjected to silica gel column chromatography to yield 0.11 g of a crystal.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05726306 |
| 출처 데이터셋 | uspto-grants-1998_03 |
| ORD ID | ord-757632750487427b80394903b6f82440 |
| 출처 메모 | uspto-grants-1998_03 |