Chlorosulfonic acid → 2-Bromo-4,5-dimethoxybenzene-1-sulfonyl chloride
반응식
[Br:1][C:2]1[CH:3]=[C:4]([O:10][CH3:11])[C:5]([O:8][CH3:9])=[CH:6][CH:7]=1.[Cl:12][S:13](O)(=[O:15])=[O:14]>ClCCl>[Br:1][C:2]1[CH:3]=[C:4]([O:10][CH3:11])[C:5]([O:8][CH3:9])=[CH:6][C:7]=1[S:13]([Cl:12])(=[O:15])=[O:14]참가 물질
4
실험 절차
To a cooled (0° C.) solution of 4-bromoveratrole (15 mL, 100 mmol) in dichloromethane (100 mL) was added dropwise chlorosufonic acid (26 mL, 400 mmol). The reaction was allowed to slowly warm to ambient temperature and maintained for 3 hours, at which time it was concentrated and diluted with ether (300 mL). The resultant solution was then washed with ice cold water (2×250 mL) and brine (100 mL), dried over magnesium sulfate, and concentrated to furnish a grayish powder (25 g, 78%).
후처리
- temperaturemaintained for 3 hours, at which time it
- concentrationwas concentrated
- additiondiluted with ether (300 mL)
- washThe resultant solution was then washed with ice cold water (2×250 mL) and brine (100 mL)
- dry with materialdried over magnesium sulfate
- concentrationconcentrated
출처 및 근거
- ORD 기록
- ord-46af6e94c9c24c6281c66808f94be677
- 출처 데이터셋
- uspto-grants-2006_04
- 특허 번호
- US07026349B2
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