Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-Chlororesorcinol → 6-Chloro-7-hydroxy coumarin
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-Chlororesorcinol | HCID 1731 | — |
| 반응물 | Ethyl alpha-benzylacetoacetate | HCID 246929 | — |
| 용매 | Sulfuric Acid | HCID 1118 | — |
| 생성물 | 6-Chloro-7-hydroxy coumarin | HCID 5393166 | 104.9% |
반응 단계
4-Chlororesorcinol (26.25 g, 0.182 mol) and ethyl 2-benzylacetoacetate (40 g, 0.182 mol) are mixed in 70% H2SO4 (350 mL) at 0° C. The reaction mixture is stirred at room temperature for 72 hours and poured into ice water. The solid is filtered and washed with water. The crude product is recrystallized from ethanol/chloroform to afford 6-chloro-7-hydroxy coumarin intermediate (37.52 g, 68.7%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07026491B2 |
| 출처 데이터셋 | uspto-grants-2006_04 |
| ORD ID | ord-279ca8169b044fe6848cbe69eaa8ad7a |
| 출처 메모 | uspto-grants-2006_04 |