Benzenesulfonic acid, 4-methyl-, compd. with pyridine (1:1) → HCID 21024036, 화합물

HRID 1795689노트

반응식

HRID 1795689 반응식
C1(C)C=CC(S([O-])(=O)=O)=CC=1.[NH+]1C=CC=CC=1.[Cl:18][CH2:19][C:20]([O:22][CH:23]1[C:24]([O:66]C(OCC)C)([CH3:65])[CH2:25][CH2:26][CH:27]([O:59]C(OCC)C)[CH2:28][C:29]([O:31][CH:32](/[C:37](/[CH3:58])=[CH:38]/[CH:39]=[CH:40]/[CH:41]([CH3:57])[CH2:42][CH:43]2[O:56][CH:44]2[CH:45]([CH3:55])[CH:46]([O:49]C(OCC)C)[CH2:47][CH3:48])[CH:33]([CH3:36])[CH:34]=[CH:35]1)=[O:30])=[O:21]>CO>[Cl:18][CH2:19][C:20]([O:22][CH:23]1[C:24]([OH:66])([CH3:65])[CH2:25][CH2:26][CH:27]([OH:59])[CH2:28][C:29]([O:31][CH:32](/[C:37](/[CH3:58])=[CH:38]/[CH:39]=[CH:40]/[CH:41]([CH3:57])[CH2:42][CH:43]2[O:56][CH:44]2[CH:45]([CH3:55])[CH:46]([OH:49])[CH2:47][CH3:48])[CH:33]([CH3:36])[CH:34]=[CH:35]1)=[O:30])=[O:21]

참가 물질

4

반응물 2

HCID 466102Benzenesulfonic acid, 4-methyl-, compd. with pyridine (1:1)HCID 21024035HCID 21024035, 화합물

생성물 1

HCID 21024036HCID 21024036, 화합물수율 70%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

Pyridinium p-toluenesulfonate (1 mg, 4.1 μmol) was added to a solution of (8E,12E,14E)-7-chloroacetoxy-3,6,21-tri(1-ethoxyethoxy)-6,10,12,16,20-pentamethyl-18,19-epoxytricosa-8,12,14-trien-11-olide (3.2 mg, 4.06 μmol) in methanol (1 mL), followed by stirring at room temperature for one hour. The reaction solution was evaporated, and the resulting residue was purified by thin layer chromatography (MERCK Silica gel 60 F254, 0.2 mm, developing solution; ethyl acetate-hexane=2:1) to obtain the title compound (1.6 mg, 70%) as a colorless oil.

후처리

  1. customThe reaction solution was evaporated
  2. customthe resulting residue was purified by thin layer chromatography (MERCK Silica gel 60 F254, 0.2 mm, developing solution; ethyl acetate-hexane=2:1)

출처 및 근거

ORD 기록
ord-b1893cbd9d8e4068a07772c5bcf37a48
출처 데이터셋
uspto-grants-2006_04
특허 번호
US07026352B1

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