2-Methylphenyl boronic acid → 2-Chloro-4-(2-methylphenyl)nicotinic acid

HRID 1795832노트

반응식

HRID 1795832 반응식
[Cl:1][C:2]1[N:10]=[CH:9][CH:8]=[C:7](I)[C:3]=1[C:4]([OH:6])=[O:5].[CH3:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=1B(O)O>>[Cl:1][C:2]1[N:10]=[CH:9][CH:8]=[C:7]([C:14]2[CH:15]=[CH:16][CH:17]=[CH:18][C:13]=2[CH3:12])[C:3]=1[C:4]([OH:6])=[O:5]

참가 물질

3

반응물 2

HCID 27332672-Methylphenyl boronic acidHCID 177501742-Chloro-4-iodonicotinic acid

생성물 1

HCID 221793522-Chloro-4-(2-methylphenyl)nicotinic acid수율 90%

실험 절차

In a similar manner to Reference Example 4, 2-chloro-4-iodonicotinic acid (Compound of Reference Example 1; 5.67 g) was reacted with 2-methylphenylboronic acid (3.00 g) to obtain 2-chloro-4-(2-methylphenyl)nicotinic acid (4.44 g, 90%).

출처 및 근거

ORD 기록
ord-470f03ff10d444899b9d28a2d8048d82
출처 데이터셋
uspto-grants-2006_04
특허 번호
US07030107B2

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