Dichloromethane → (2R,4R)-Methyl 4-methoxypyrrolidine-2-carboxylate
반응식
[CH3:1][O:2][C:3]([C@H:5]1[CH2:9][C@@H:8]([O:10][CH3:11])[CH2:7][N:6]1C(C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1)=[O:4].C(Cl)Cl.C(O)(C(F)(F)F)=O>O>[CH3:1][O:2][C:3]([C@H:5]1[CH2:9][C@@H:8]([O:10][CH3:11])[CH2:7][NH:6]1)=[O:4]참가 물질
5
실험 절차
To a flask containing 3 (4.67 g, 11.6 mmol) was added a solution of CH2Cl2 (27 mL), water (0.3 mL), and TFA (3.0 mL, 38.9 mmol). The solution was stirred at RT for 3 h before concentrating under reduced pressure to reveal impure 4. MS: APCI (AP+): 160.1 (M)+.
후처리
- concentrationbefore concentrating under reduced pressure
출처 및 근거
- ORD 기록
- ord-add42f3ceafa41eebaf436121f8210db
- 출처 데이터셋
- uspto-grants-2006_04
- 특허 번호
- US07030141B2
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