Methanol → HCID 178497357, 화합물

반응식

[Cl:1][CH2:2][C:3]1[NH:7][C:6]2[CH:8]=[CH:9][C:10]([C:12]([OH:14])=[O:13])=[CH:11][C:5]=2[N:4]=1.S(=O)(=O)(O)O.[CH3:20]O>>[Cl:1][CH2:2][C:3]1[NH:7][C:6]2[CH:8]=[CH:9][C:10]([C:12]([O:14][CH3:20])=[O:13])=[CH:11][C:5]=2[N:4]=1

참가 물질

반응물 3

HCID 887Methanol

HCID 1118Sulfuric Acid

HCID 178524165HCID 178524165, 화합물

생성물 1

HCID 178497357HCID 178497357, 화합물수율 71%

실험 절차

To 2-(Chloromethyl)-1H-benzimidazole-5-carboxylic acid (4) (0.5 g; 2.4 mmole) suspended in anhydrous methanol (20 ml) was added dropwise Sulfuric acid (0.2 ml). The reaction mixture was maintained at reflux for 16 hours. The solvent was evaporated to give the crude oily product, which was purified by column chromatography (silica, 10% methanol: dichloromethane) to obtain 0.4 g (71% yield) of product 5.

후처리

temperatureThe reaction mixture was maintained
temperatureat reflux for 16 hours
customThe solvent was evaporated
customto give the crude oily product, which
customwas purified by column chromatography (silica, 10% methanol: dichloromethane)

출처 및 근거

ORD 기록: ord-868a4287ec894ad8a8a4bf6d592a44da
출처 데이터셋: uspto-grants-2006_04
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07030150B2

반응 노트

불러오는 중…