Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Acetic Anhydride → 1-[2-(Chloromethyl)-1h-benzimidazol-1-yl]ethanone
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Acetic Anhydride | HCID 7918 | — |
| 반응물 | 2-Chloromethylbenzimidazole | HCID 78571 | — |
| 촉매 | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| 생성물 | 1-[2-(Chloromethyl)-1h-benzimidazol-1-yl]ethanone | HCID 267404 | 57% |
반응 단계
2-(Chloromethyl)-1H-benzimidazole (3.32 g, 0.02 mol) and DMAP (0.2 g) in Ac2O (50 ml) were refluxed for 8 h. The excess Ac2O was evaporated under vacuum and the residue was purified by column chromatography (silica, EtOAc:hexanes 2:1, first fraction) to obtain 2.37 g of product 7 (57%)
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07030150B2 |
| 출처 데이터셋 | uspto-grants-2006_04 |
| ORD ID | ord-96bd3d86a5bb4ad297ba9d20200d8e5a |
| 출처 메모 | uspto-grants-2006_04 |