참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Thionyl Chloride | HCID 24386 | — |
| 반응물 | Benzeneacetic acid, 4-ethoxy- | HCID 78631 | — |
| 용매 | Benzene | HCID 241 | — |
| 생성물 | 2-(4-ethoxyphenyl)acetyl Chloride | HCID 11629782 | 94.2% |
반응 단계
To a stirred solution of (4-ethoxyphenyl)acetic acid (10.0 g, 55.5 mmol) in benzene (100 mL) was added thionyl chloride (50 mL, 68.5 mmol) and the reaction mixture was stirred at 80° C. for 2 hours. The solvent was evaporated in vacuo and the crude product was purified by distillation (bp 86° C., 0.4 Torr) to provide the title compound (10.39 g, 94%) as a yellow oil. MS of methyl ester: MS (ESI) (M+H)+=194.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07030139B2 |
|---|
| 출처 데이터셋 | uspto-grants-2006_04 |
|---|
| ORD ID | ord-a4973ff8d05341179cbddab8e5d61986 |
|---|
| 출처 메모 | uspto-grants-2006_04 |
|---|
