Hydrazine → 1-Amino-3-methoxy-1H-pyrrole-2,4-dicarboxylic acid diethyl ester

HRID 1796623노트

반응식

HRID 1796623 반응식
[CH2:1]([O:3][C:4]([C:6]1[N:7]([N:18]2C(=O)C3C(=CC=CC=3)C2=O)[CH:8]=[C:9]([C:13]([O:15][CH2:16][CH3:17])=[O:14])[C:10]=1[O:11][CH3:12])=[O:5])[CH3:2].NN>CCO>[CH2:1]([O:3][C:4]([C:6]1[N:7]([NH2:18])[CH:8]=[C:9]([C:13]([O:15][CH2:16][CH3:17])=[O:14])[C:10]=1[O:11][CH3:12])=[O:5])[CH3:2]

참가 물질

4

반응물 2

HCID 9321HydrazineHCID 693272701-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-3-methoxy-1H-pyrrole-2,4-dicarboxylic acid diethyl ester

생성물 1

HCID 129859111-Amino-3-methoxy-1H-pyrrole-2,4-dicarboxylic acid diethyl ester수율 74.1%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A mixture of 393D (0.58 g, 1.58 mmol) and NH2NH2 (60 μl, 2.21 mmol) in EtOH (5 ml) was stirred at rt overnight, filtered through Celite, the filtrate was concentrated and the residue was purified by silica gel flash column chromatography to give 393E (0.30 g, 75%) (0%-5% EtOAc—CH2Cl2).

후처리

  1. filtrationfiltered through Celite
  2. concentrationthe filtrate was concentrated
  3. customthe residue was purified by silica gel flash column chromatography

출처 및 근거

ORD 기록
ord-4f3ffa5678524a1a8aa0ce1e435ed189
출처 데이터셋
uspto-grants-2006_04
특허 번호
US07030112B2

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