Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Acetic Acid → diethyl 1H-pyrrole-2,5-dicarboxylate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Acetic Acid | HCID 176 | — |
| 반응물 | Potassium Cyanide | HCID 9032 | — |
| 반응물 | ethyl 5-formyl-1H-pyrrole-2-carboxylate | HCID 321485 | — |
| 촉매 | Manganese dioxide | HCID 14801 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | diethyl 1H-pyrrole-2,5-dicarboxylate | HCID 21025083 | 76.7% |
반응 단계
To a mixture of 406A (167 mg, 1.0 mmol), KCN (325.6 mg, 5.0 mmol) in anhydrous EtOH (20 ml) was added AcOH (85.9 μl, 1.5 mmol) followed by activated MnO2 (1.643 g, 20 mmol). The reaction was stirred overnight. After workup, the residue was purified by silica gel flash column chromatography to give 406B (162 mg, 77%) as a pinkish solid (25% EtOAc—hexanes).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07030112B2 |
| 출처 데이터셋 | uspto-grants-2006_04 |
| ORD ID | ord-73c257903a4e4b13ab81a84fd824f0af |
| 출처 메모 | uspto-grants-2006_04 |