3-Chloro-8-thia-4,6-diazatricyclo[7.4.0.0,2,7]trideca-1(9),2,4,6-tetraene → 4-Methyl-4-(5,6,7,8-tetrahydro-benzo[4,5]thieno[2,3-d]pyrimidin-4-ylamino)-piperidine-1-carboxylic acid tert-butyl ester

HRID 1796727

반응식

HRID 1796727 반응식
Cl[C:2]1[C:3]2[C:10]3[CH2:11][CH2:12][CH2:13][CH2:14][C:9]=3[S:8][C:4]=2[N:5]=[CH:6][N:7]=1.[C:15]([O:19][C:20]([N:22]1[CH2:27][CH2:26][C:25]([NH2:29])([CH3:28])[CH2:24][CH2:23]1)=[O:21])([CH3:18])([CH3:17])[CH3:16]>>[C:15]([O:19][C:20]([N:22]1[CH2:27][CH2:26][C:25]([CH3:28])([NH:29][C:2]2[C:3]3[C:10]4[CH2:11][CH2:12][CH2:13][CH2:14][C:9]=4[S:8][C:4]=3[N:5]=[CH:6][N:7]=2)[CH2:24][CH2:23]1)=[O:21])([CH3:18])([CH3:16])[CH3:17]

참가 물질

3

반응물 2

HCID 6995153-Chloro-8-thia-4,6-diazatricyclo[7.4.0.0,2,7]trideca-1(9),2,4,6-tetraeneHCID 11310432tert-Butyl 4-amino-4-methylpiperidine-1-carboxylate

생성물 1

HCID 210265454-Methyl-4-(5,6,7,8-tetrahydro-benzo[4,5]thieno[2,3-d]pyrimidin-4-ylamino)-piperidine-1-carboxylic acid tert-butyl ester

실험 절차

The title compound was prepared (373.9 mg, 93%) from 4-chloro-5,6,7,8-tetrahydro-benzo[4,5]thieno[2,3-d]pyrimidine (224 mg, 1 mmol) and 4-amino-4-methyl-piperidine-1-carboxylic acid tert-butyl ester (235.4 mg, 1.1 mmol) by following the procedure described for preparation 9. 1H NMR (400 MHz, CDCl3): δ (ppm) 8.39 (s, 1H), 3.33 (m, 4H), 3.10 (m, 2H), 2.87 9M, 2H), 1.93 (m, 4H), 1.66 (m, 4H), 1.40 (s, 9H), 1.22 (s, 3H); MS (SEI): m/z: Calculated: 402.6; Observed: 403.2 (M++1).

후처리

  1. customdescribed for preparation 9

출처 및 근거

ORD 기록
ord-6bbdc03acac84f9bb91d07ee89585762
출처 데이터셋
uspto-grants-2006_04
특허 번호
US07030240B2

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