Ethyl 2-fluoro-5-nitrobenzoate → Ethyl 5-amino-2-fluorobenzoate
반응식
[F:1][C:2]1[CH:12]=[CH:11][C:10]([N+:13]([O-])=O)=[CH:9][C:3]=1[C:4]([O:6][CH2:7][CH3:8])=[O:5]>C(O)C.[Pd]>[NH2:13][C:10]1[CH:11]=[CH:12][C:2]([F:1])=[C:3]([CH:9]=1)[C:4]([O:6][CH2:7][CH3:8])=[O:5]참가 물질
4
실험 절차
Ethyl 2-fluoro-5-nitrobenzoate (0.63 g) was dissolved in ethanol (10 ml), and 10% Pd-C (0.064 g) was added to the solution. The mixture was subjected to catalytic reduction at room temperature for 7 hr. The reaction solution was filtered through Celite, and was washed with ethanol. The solvent was then removed by distillation under the reduced pressure to give 0.55 g (100%) of ethyl 5-amino-2-fluorobenzoate.
후처리
- filtrationThe reaction solution was filtered through Celite
- washwas washed with ethanol
- customThe solvent was then removed by distillation under the reduced pressure
출처 및 근거
- ORD 기록
- ord-bcb8d7352b974746b20edd5132d4f95a
- 출처 데이터셋
- uspto-grants-2006_04
- 특허 번호
- US07030120B2
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