N-Methylcyclohexylamine → n-Cyclohexyl-5-[4-(3,3-diphenyl-1-propyl)piperazin-1-yl]-n-methyl-2-methylbenzamide
반응식
C(N(C1CCCCC1)C(=O)C1C=C([N:12]2[CH2:17][CH2:16][N:15]([CH2:18][CH2:19][CH:20]([C:27]3[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=3)[C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=3)[CH2:14][CH2:13]2)C=CC=1F)C=C.[CH3:41][C:42]1[CH:50]=[CH:49][C:48]([N+]([O-])=O)=[CH:47][C:43]=1[C:44]([OH:46])=O.[CH3:54][NH:55][CH:56]1[CH2:61][CH2:60][CH2:59][CH2:58][CH2:57]1>>[CH:56]1([N:55]([CH3:54])[C:44](=[O:46])[C:43]2[CH:47]=[C:48]([N:12]3[CH2:17][CH2:16][N:15]([CH2:18][CH2:19][CH:20]([C:21]4[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=4)[C:27]4[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=4)[CH2:14][CH2:13]3)[CH:49]=[CH:50][C:42]=2[CH3:41])[CH2:61][CH2:60][CH2:59][CH2:58][CH2:57]1참가 물질
4
실험 절차
Steps (a) and (b) of Example 59 were repeated, except that 2-methyl-5-nitrobenzoic acid was used instead of 2-fluoro-5-nitrobenzoic acid. Step (c) of Example 59 was then repeated, except that N-methylcyclohexylamine was used instead of N-allylcyclohexylamine. Thus, the title compound was prepared.
출처 및 근거
- ORD 기록
- ord-d60ff229edac49a398152525d8142c12
- 출처 데이터셋
- uspto-grants-2006_04
- 특허 번호
- US07030120B2
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