2-benzyl-7-piperazinyl-2H-phthalazin-1-one → 2-Benzyl-7-[4-[3-[9-(2,2,2-trifluoroethylcarbamoyl)-9H-xanthen-9-yl]propyl]-piperazin-1-yl]-2H-phthalazin-1-one

HRID 1796773노트

반응식

HRID 1796773 반응식
[F:1][C:2]([F:26])([F:25])[CH2:3][NH:4][C:5]([C:7]1([CH2:21][CH2:22][CH2:23]Br)[C:20]2[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=2[O:14][C:13]2[C:8]1=[CH:9][CH:10]=[CH:11][CH:12]=2)=[O:6].[CH2:27]([N:34]1[N:43]=[CH:42][C:41]2[C:36](=[CH:37][C:38]([N:44]3[CH2:49][CH2:48][NH:47][CH2:46][CH2:45]3)=[CH:39][CH:40]=2)[C:35]1=[O:50])[C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1>>[CH2:27]([N:34]1[N:43]=[CH:42][C:41]2[C:36](=[CH:37][C:38]([N:44]3[CH2:45][CH2:46][N:47]([CH2:23][CH2:22][CH2:21][C:7]4([C:5](=[O:6])[NH:4][CH2:3][C:2]([F:26])([F:25])[F:1])[C:20]5[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=5[O:14][C:13]5[C:8]4=[CH:9][CH:10]=[CH:11][CH:12]=5)[CH2:48][CH2:49]3)=[CH:39][CH:40]=2)[C:35]1=[O:50])[C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1

참가 물질

3

반응물 2

HCID 221802782-benzyl-7-piperazinyl-2H-phthalazin-1-oneHCID 221805833-[9-(2,2,2-Trifluoroethylcarbamoyl)-9H-xanthen-9-yl]propyl bromide

생성물 1

HCID 221801742-Benzyl-7-[4-[3-[9-(2,2,2-trifluoroethylcarbamoyl)-9H-xanthen-9-yl]propyl]-piperazin-1-yl]-2H-phthalazin-1-one

실험 절차

Step (c) of Example 92 was repeated, except that the compound prepared in step (b) of Example 114 and the compound prepared in step (e) of Example 137 were used as the starting compounds. Thus, the title compound was obtained.

출처 및 근거

ORD 기록
ord-ac5c45007cc34363bb2f5ac98ddc5dfa
출처 데이터셋
uspto-grants-2006_04
특허 번호
US07030120B2

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