4-[9-(2,2,2-Trifluoroethylcarbamoyl)-9H-xanthen-9-yl]butyl bromide → ethyl 2-methyly-3-[4-[4-[9-(2,2,2-trifluoroethylcarbamoyl)-9H-xanthen-9-yl]butyl]piperazin-1-yl]benzoate
반응식
[CH3:1][C:2]1[C:12]([N:13]2[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]2)=[CH:11][CH:10]=[CH:9][C:3]=1[C:4]([O:6][CH2:7][CH3:8])=[O:5].[F:19][C:20]([F:45])([F:44])[CH2:21][NH:22][C:23]([C:25]1([CH2:39][CH2:40][CH2:41][CH2:42]Br)[C:38]2[CH:37]=[CH:36][CH:35]=[CH:34][C:33]=2[O:32][C:31]2[C:26]1=[CH:27][CH:28]=[CH:29][CH:30]=2)=[O:24]>>[CH2:1]=[C:2]1[C:12]([N:13]2[CH2:14][CH2:15][N:16]([CH2:42][CH2:41][CH2:40][CH2:39][C:25]3([C:23](=[O:24])[NH:22][CH2:21][C:20]([F:45])([F:19])[F:44])[C:26]4[CH:27]=[CH:28][CH:29]=[CH:30][C:31]=4[O:32][C:33]4[C:38]3=[CH:37][CH:36]=[CH:35][CH:34]=4)[CH2:17][CH2:18]2)=[CH:11][CH:10]=[CH:9][CH:3]1[C:4]([O:6][CH2:7][CH3:8])=[O:5]참가 물질
3
실험 절차
The procedure of step (b) of Example 1 was repeated, except that the compound prepared in step (a) of Example 53 and the compound prepared in step (a) of Example 96 were used as the starting compounds. Thus, ethyl 2-methyly-3-[4-[4-[9-(2,2,2-trifluoroethylcarbamoyl)-9H-xanthen-9-yl]butyl]piperazin-1-yl]benzoate was obtained.
출처 및 근거
- ORD 기록
- ord-0e0e5e97bd4e4d14a0803bdea59bccff
- 출처 데이터셋
- uspto-grants-2006_04
- 특허 번호
- US07030120B2
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