Water → HCID 22175090, 화합물

HRID 1797021노트

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HRID 1797021 반응식
[O-:1][CH2:2][CH3:3].[Na+].F[C:6]1[CH:11]=[CH:10][N:9]=[CH:8][C:7]=1[O:12][CH2:13][O:14][CH2:15][CH2:16][Si:17]([CH3:20])([CH3:19])[CH3:18].O>C(O)C>[CH2:2]([O:1][C:6]1[CH:11]=[CH:10][N:9]=[CH:8][C:7]=1[O:12][CH2:13][O:14][CH2:15][CH2:16][Si:17]([CH3:20])([CH3:19])[CH3:18])[CH3:3]

참가 물질

5

반응물 3

HCID 962WaterHCID 2723922Sodium ethoxideHCID 22175082HCID 22175082, 화합물

생성물 1

HCID 22175090HCID 22175090, 화합물수율 50.6%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

To a stirred solution of sodium ethoxide (0.9 g, 13 mmol) in ethanol (10 mL) was added all at once 10 (1.07 g, 4.4 mmol). The resulting mixture was stirred at room temperature for 48 hours, then poured into water (100 mL). The resulting mixture was extracted with ether (3×50 mL). The ether extracts were combined, dried (MgSO4) and concentrated. The resulting amber oil was chromatographed (silica gel, hexane-acetone, 4:1) to give 11 as a yellow oil (0.6 g).

후처리

  1. extractionThe resulting mixture was extracted with ether (3×50 mL)
  2. dry with materialdried (MgSO4)
  3. concentrationconcentrated
  4. customThe resulting amber oil was chromatographed (silica gel, hexane-acetone, 4:1)

출처 및 근거

ORD 기록
ord-bf330146a6b147a696b74fb28f54b4fc
출처 데이터셋
uspto-grants-2006_04
특허 번호
US07034035B2

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