HCID 22176567, 화합물 → HCID 22176564, 화합물

HRID 1797193노트

반응식

HRID 1797193 반응식
[OH:1][C:2]([C:12]1[CH:17]=[CH:16][C:15]([N+:18]([O-])=O)=[CH:14][CH:13]=1)([CH3:11])[CH2:3][NH:4][S:5]([CH:8]([CH3:10])[CH3:9])(=[O:7])=[O:6].[H][H]>C(OCC)(=O)C.[Pd]>[NH2:18][C:15]1[CH:14]=[CH:13][C:12]([C:2]([OH:1])([CH3:11])[CH2:3][NH:4][S:5]([CH:8]([CH3:9])[CH3:10])(=[O:7])=[O:6])=[CH:17][CH:16]=1

참가 물질

5

반응물 2

HCID 22176567HCID 22176567, 화합물HCID 178418361HCID 178418361, 화합물

생성물 1

HCID 22176564HCID 22176564, 화합물수율 42%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 8857Ethyl Acetate용매

실험 절차

900 mg of [2-hydroxy-2-(4-nitrophenyl)propyl][(methylethyl)sulfonyl]amine and 1.2 equivalence of 10% Pd/C in ethyl acetate (50 mL) were subjected to a hydrogen atmosphere while shaking at 60 psi for 3 hours. Solution was filtered through a Celite® mat and the resulting filtrate was concentrated under reduced vacuum to yield 720 mg as an oil. This material was purified via silica gel chromatography employing the Chromatotron and using a 4000 micron rotor while eluting with a solvent of hexane/ethyl acetate 1:1 to yield the intermediate title compound (340 mg, 42%) as a tan solid. Ion spray M.S. 271.4 (M*−1).

후처리

  1. filtrationSolution was filtered through a Celite® mat
  2. concentrationthe resulting filtrate was concentrated under reduced vacuum
  3. customto yield 720 mg as an oil
  4. customThis material was purified via silica gel chromatography
  5. washwhile eluting with a solvent of hexane/ethyl acetate 1:1

출처 및 근거

ORD 기록
ord-1f39119d00e942d5b93415f20f62844e
출처 데이터셋
uspto-grants-2006_04
특허 번호
US07034045B1

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