1-Butanaminium, N,N,N-tributyl-, fluoride, hydrate → HCID 9833987, 화합물

HRID 1797398노트

반응식

HRID 1797398 반응식
[OH2:1].[F-].C([N+](CCCC)(CCCC)CCCC)CCC.[Si]([CH2:27][CH2:28][C@H:29]([OH:35])[C:30]([CH3:34])([CH3:33])[C:31]#[N:32])(C(C)(C)C)(C)C>O1CCCC1>[OH:1][CH2:27][CH2:28][C@H:29]([OH:35])[C:30]([CH3:34])([CH3:33])[C:31]#[N:32]

참가 물질

4

반응물 2

HCID 162116731-Butanaminium, N,N,N-tributyl-, fluoride, hydrateHCID 235679315-tert-butyldimethylsilyl-2,2-dimethyl-3(S)hydroxy-pentane-nitrile2회

생성물 1

HCID 9833987HCID 9833987, 화합물

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

12.18 g (46.61 mmol) of tetrabutylammonium fluoride hydrate is added to a solution that consists of 3 g (11.65 mmol) of 5-tert-butyldimethylsilyl-2,2-dimethyl-3(S)hydroxy-pentane-nitrile of the title compound of Example 8b, dissolved in 40 ml of tetrahydrofuran, and it is stirred for 16 hours at room temperature. Then, it is evaporated to the dry state in a vacuum. The residue is purified by RP-18 chromatography (mobile solvent: acetonitrile/water gradient).

후처리

  1. customThen, it is evaporated to the dry state in a vacuum
  2. customThe residue is purified by RP-18 chromatography (mobile solvent: acetonitrile/water gradient)

출처 및 근거

ORD 기록
ord-2c798bcd99a549069115dc8688a4a024
출처 데이터셋
uspto-grants-2006_04
특허 번호
US07034165B2

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