Water → 1H-Indole, 6-methyl-

HRID 1798022노트

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HRID 1798022 반응식
[C:1]([CH:3]([C:14]1[CH:19]=[CH:18][C:17]([CH3:20])=[CH:16][C:15]=1[N+:21]([O-])=O)C(OCC1C=CC=CC=1)=O)#N.O>[Pd].C(O)C>[CH3:20][C:17]1[CH:16]=[C:15]2[C:14]([CH:3]=[CH:1][NH:21]2)=[CH:19][CH:18]=1

참가 물질

5

반응물 2

HCID 962WaterHCID 10935797Benzyl 2-cyano-2-(2-nitro-4-methylphenyl)ethanoate

생성물 1

HCID 1379281H-Indole, 6-methyl-수율 74%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

실험 절차

a mixture of benzyl 2-cyano-2-(2-nitro-4-methylphenyl)ethanoate (13 mmol), 5% palladium (0.84 g), water (4 mL) and ethanol (40 mL) is hydrogenated under 50 psi for 18 hours at 25° C. The catalyst is eliminated by filtration on celite and the solid is washed with ethanol. The filtrate obtained is evaporated under vacuum and the residue is purified by chromatography on silica gel (eluent: CH2Cl2/pentane, 2/1) in order to produce 6-methylindole with a yield of 74%.

후처리

  1. filtrationThe catalyst is eliminated by filtration on celite
  2. washthe solid is washed with ethanol
  3. customThe filtrate obtained
  4. customis evaporated under vacuum
  5. customthe residue is purified by chromatography on silica gel (eluent: CH2Cl2/pentane, 2/1) in order

출처 및 근거

ORD 기록
ord-d89ffe2ad0ef44d999e2bc5fb2b3c936
출처 데이터셋
uspto-grants-2013_01
특허 번호
US08343964B2

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