2-Methoxy-4-(2-tetrahydropyranyl)oxy-6-methylbenzaldehyde → 4-Hydroxy-2-methoxy-6-methylbenzaldehyde

HRID 1798142노트

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HRID 1798142 반응식
[CH3:1][O:2][C:3]1[CH:10]=[C:9]([O:11]C2CCCCO2)[CH:8]=[C:7]([CH3:18])[C:4]=1[CH:5]=[O:6]>CO>[OH:11][C:9]1[CH:8]=[C:7]([CH3:18])[C:4]([CH:5]=[O:6])=[C:3]([O:2][CH3:1])[CH:10]=1

참가 물질

3

반응물 1

HCID 107531782-Methoxy-4-(2-tetrahydropyranyl)oxy-6-methylbenzaldehyde

생성물 1

HCID 143093964-Hydroxy-2-methoxy-6-methylbenzaldehyde수율 78%

시약·촉매·용매 1

HCID 887Methanol용매

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온도
50 °C

실험 절차

Crude 2-methoxy-6-methyl-4-(tetrahydro-pyran-2-yloxy)-benzaldehyde from the above step was diluted with MeOH (30 mL), then treated with Amberlyst® 15 (0.10 g). The suspension was heated at 50° C. for 1 h. The resin was removed by hot filtration and the filtrate was concentrated to a yellow semi-solid. The residue was recrystallized from MeOH and hexanes to give 4-hydroxy-2-methoxy-6-methyl-benzaldehyde (4.16 g, 78% over 2 steps), as a yellow solid. 1H NMR (400 MHz, CDCl3) δ 10.47 (s, 1H), 6.32 (s, 1H), 6.25 (s, 1H), 5.49 (br s, 1H), 3.87 (s, 3H), 2.56 (s, 3H).

후처리

  1. customThe resin was removed by hot filtration
  2. concentrationthe filtrate was concentrated to a yellow semi-solid
  3. customThe residue was recrystallized from MeOH and hexanes

출처 및 근거

ORD 기록
ord-8ff27799a5054923883787024a39582c
출처 데이터셋
uspto-grants-2013_01
특허 번호
US08343944B2

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