4-((4-Isopropyl-piperazin-1-yl)methyl)-phenyl boronic acid → HCID 178424463, 화합물
반응식
[OH:1][C:2]1[N:7]=[C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[C:10]([CH3:14])[N:9]=2)[CH:5]=[C:4]([C:15]2[CH:16]=[N:17][CH:18]=[C:19]([C:21]3[CH:26]=[CH:25][C:24]([C:27]([N:29]4[CH2:34][CH2:33][N:32]([CH:35]([CH3:37])[CH3:36])[CH2:31][CH2:30]4)=O)=[CH:23][CH:22]=3)[CH:20]=2)[CH:3]=1.C(N1CCN(CC2C=CC(B(O)O)=CC=2)CC1)(C)C>>[CH:35]([N:32]1[CH2:31][CH2:30][N:29]([CH2:27][C:24]2[CH:23]=[CH:22][C:21]([C:19]3[CH:20]=[C:15]([C:4]4[CH:3]=[C:2]([OH:1])[N:7]=[C:6]([C:8]5[CH:13]=[CH:12][CH:11]=[C:10]([CH3:14])[N:9]=5)[CH:5]=4)[CH:16]=[N:17][CH:18]=3)=[CH:26][CH:25]=2)[CH2:34][CH2:33]1)([CH3:37])[CH3:36]참가 물질
3
실험 절차
is prepared analogously to [4-(6′-Hydroxy-6-methyl-[2,2′;4′,3″]terpyridin-5″-yl)-phenyl]-(4-isopropyl-piperazin-1-yl)-methanone (Example 2.109) by replacing (4-isopropyl-piperazin-1-yl)-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-methanone with 4-(4-Isopropyl-piperazin-1-ylmethyl)-phenyl boronic acid (Intermediate B3).
출처 및 근거
- ORD 기록
- ord-62cd4cc26d654666bbf168ec550396a5
- 출처 데이터셋
- uspto-grants-2013_01