3,4,5-Trimethyl-piperazine-1-carboxylic acid benzyl ester → 1,2,6-Trimethylpiperazine

HRID 1798551노트

반응식

HRID 1798551 반응식
C(OC([N:11]1[CH2:16][CH:15]([CH3:17])[N:14]([CH3:18])[CH:13]([CH3:19])[CH2:12]1)=O)C1C=CC=CC=1>CCO.[Pd]>[CH3:18][N:14]1[CH:15]([CH3:17])[CH2:16][NH:11][CH2:12][CH:13]1[CH3:19]

참가 물질

4

반응물 1

HCID 687346163,4,5-Trimethyl-piperazine-1-carboxylic acid benzyl ester

생성물 1

HCID 219737471,2,6-Trimethylpiperazine

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

실험 절차

Under an inert atmosphere of nitrogen, 3,4,5-trimethyl-piperazine-1-carboxylic acid benzyl ester (1 eq, 1.87 mmol, 0.49 g) is dissolved in EtOH (20 ml) and palladium on carbon (0.1 eq, 0.187 mmol, 0.2 g) is added. The reaction is stirred at room temperature under an atmosphere of hydrogen for 4 hrs. The reaction mixture is filtered through Celite® and the solvent evaporated under vacuo to afford the title compound.

후처리

  1. filtrationThe reaction mixture is filtered through Celite®
  2. customthe solvent evaporated under vacuo

출처 및 근거

ORD 기록
ord-3078ad1b2ace4a1baf621956ef064d5c
출처 데이터셋
uspto-grants-2013_01
특허 번호
US08343966B2

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