Trifluoroacetic acid → 3-(5-Methyl-1,3,4-oxadiazol-2-yl)phenol

반응식

COC1C=CC(C[O:8][C:9]2[CH:10]=[C:11]([C:15]3[O:16][C:17]([CH3:20])=[N:18][N:19]=3)[CH:12]=[CH:13][CH:14]=2)=CC=1.C(O)(C(F)(F)F)=O>>[CH3:20][C:17]1[O:16][C:15]([C:11]2[CH:10]=[C:9]([OH:8])[CH:14]=[CH:13][CH:12]=2)=[N:19][N:18]=1

참가 물질

반응물 2

HCID 6422Trifluoroacetic acid

HCID 58128485HCID 58128485, 화합물

생성물 1

HCID 129617433-(5-Methyl-1,3,4-oxadiazol-2-yl)phenol

실험 절차

2-{3-[(4-Methoxybenzyl)oxy]phenyl}-5-methyl-1,3,4-oxadiazole (100 mg, 0.338 mmol) was treated with 0.5 mL TFA and was stirred at room temperature for 10 min. Excess TFA was removed under vacuum and the residue was purified by column chromatography using a 24 gram biotage silica gel cartridge eluting with 20-50% ethyl acetate/hexanes (gradient) to give the product as white solid. LRMS calc: 176.1; obs: 177.2 (M+1).

후처리

customExcess TFA was removed under vacuum
customthe residue was purified by column chromatography
washeluting with 20-50% ethyl acetate/hexanes (gradient)

출처 및 근거

ORD 기록: ord-e5db634352fa4d798eb663fcfaa7623b
출처 데이터셋: uspto-grants-2013_01
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08343990B2

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